Portal do Conhecimento
  Português | Inglês

Portal do Conhecimento >
BDCV - Biblioteca Digital de Cabo Verde >
BDCV - Documentos sobre Cabo Verde >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10961/1260

Title: Analysis of malaria associated genetic traits in Cabo Verde, a melting pot of European and sub Saharan settlers
Authors: Alves, Joana
Machado, Patrícia
Silva, João
Gonçalves, Nilza
Ribeiro, Letícia
Faustino, Paula
Rosário, Virgílio Estólio do
Manco, Licínio
Gusmão, Leonor
Amorim, António
Arez, Ana Paula
Keywords: Hemoglobin S Malaria
Pyruvate Kinase
Cabo Verde
Issue date: 17-Oct-2009
Publisher: Elsevier
Abstract: Malaria has occurred in the Cabo Verde archipelago with epidemic characteristics since its colonization. Nowadays, it occurs in Santiago Island alone and though prophylaxis is not recommended by the World Health Organization, studies have highlight the prospect of malaria becoming a serious public health problem as a result of the presence of antimalarial drug resistance associated with mutations in the parasite populations and underscore the need for tighter surveillance. Despite the presumptive weak immune status of the population, severe symptoms of malaria are not observed and many people present a subclinical course of the disease. No data on the prevalence of sicklecell trait and red cell glucose-6-phosphate dehydrogenase deficiency (two classical genetic factors associated with resistance to severe malaria) were available for the Cabo Verde archipelago and, therefore, we studied the low morbidity from malaria in relation to the particular genetic characteristics of the human host population. We also included the analysis of the pyruvate kinase deficiency associated gene, reported as putatively associated with resistance to the disease. Allelic frequencies of the polymorphisms examined are closer to European than to African populations and no malaria selection signatures were found. No association was found between the analyzed human factors and infection but one result is of high interest: a linkage disequilibrium test revealed an association of distant loci in the PKLR gene and adjacent regions, only in non-infected individuals. This could mean a more conserved gene region selected in association to protection against the infection and/or the disease.
URI: http://hdl.handle.net/10961/1260
ISSN: 1079-9796
Appears in Collections:BDCV - Documentos sobre Cabo Verde

Files in This Item:

File Description SizeFormat
My article_Host factors (2).pdf385,29 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


NOSI Universidade do Minho  

Portal do Conhecimento  - Feedback - portaldoconhecimento@mesci.gov.cv - Tel. +238 - 2610232