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Please use this identifier to cite or link to this item: http://hdl.handle.net/10961/1262

Title: Assessement of Malaria Transmission in an Area with Very Low Mosquito Density
Authors: Pinto, J.
Sousa, C. A.
Arez, A. P.
Alves, Joana
Modiano, D.
Petrarca, V.
Charlwood, J. D.
Rosario, V. E.
Keywords: Plasmodium falciparum
Anopheles arabiensis
Malaria transmission
Cabo Verde
Anti-CSP ELlSA
Issue date: 8-Sep-1998
Abstract: The increase in world travel in recent years, especially to and from areas where vector-borne diseases are endemic, has resulted in a substantial rise in imported cases of those diseases. In particular, malaria is a cause of concern. In those countries at the edge of its distribution, it can be difficult to distinguish between autochthonous and imported cases. However, distinguishing between the two is important because of the different allocation of resources to combat the disease that each requires. In general, observation of the various stages of parasite development in wild-caught female mosquitoes is considered evidence of autochthonous transmission. Observation of oocysts in the mosquito mid-gut testifies that mosquitoes are susceptible to infection but conclusions cannot be reached about their ability to complete the transmission cycle. Perhaps the best indication of autochthonous transmission is microscopic observation of sporozoites in mosquito salivary glands, since this detects parasites ready to be inoculated (BELER et al., 1990). Detection of circumsporozoite protein (CSP)(BURKOT, WILLIAMS & SCHNEIDER, 1984) in dry mosquito thoraxes, by Enzyme Linked Immunosorbent Assay (ELISA) is also widely used to determine transmission, especially when large numbers of mosquitoes need to be processed. Such assays provide information about the parasite species infecting the mosquito (BURKOT & WIRTZ, 1986; WIRTZ et al., 1987; BELER et al., 1990).
URI: http://hdl.handle.net/10961/1262
Appears in Collections:BDCV - Documentos sobre Cabo Verde

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